7th ENEA Virtual Workshop,Dubrovnik, Croatia, 10-11 December 2021

Friday, 10 December 2021
09:20-09:30Workshop opening 

Session 1: Diagnosis and subtyping of Cushing’s syndrome

●       Clinical presentation and etiology of Cushing’s syndrome– data from ERCUSYN – E. Valassi

●       Diagnostic workup for Cushing’s syndrome – S. Tsagarakis

●       Novel imaging modalities in Cushing’s disease – M. Gurnell

10:45-10:55Coffee break 

Session 2: Basic science/Molecular aspects of CS

●       Genetics of Cushing’s disease – M. Theodoropoulou

●       Genetic and molecular causes of adrenocortical hyperplasia – G. Assié

11:45-12:25DEBATE 1:  Should IPSS be performed in patients with ACTH dependant CS? PRO and CON – J. Newell-Price/ A. Tabarin 
12:25-12:35Coffee break 

Session 3: Comorbidities in patients with glucocorticoid excess

●       Metabolic side effects of glucocorticoids – M. Korbonits

●       Long-term consequences of cortisol excess on the brain – A. Pereira

●       Cardiovascular complications of Cushing’s syndrome – R. Clayton

●       Bone complications of Cushing’s syndrome – N. Gittoes

●       Coagulation abnormalities in Cushing’s syndrome – R. Feelders

14:15-15:00Lunch break 

ENEA Young Investigator Symposium

  • USP8 mutations in corticotroph tumors: clinical-biochemical features and pharmacological implications – A.Albani
  • Molecular mechanisms involved in somatostatin receptors regulation in corticotroph tumors: the role of cytoskeleton and USP8 mutations – E.Peverelli
  • Mapping the transcriptomic and epigenetic landscapes of corticotrophs and precursors at single nucleus resolution – Frederique Ruf-Zamojski 
-16:45Rolf Gaillard Prize Lecture 
16:45-18:15Industry symposium 
Saturday, 11 December 2021 


Pitfalls in the testing and diagnosis of Cushing’s syndrome

P. Trainer


Challenges in neuroimaging of Cushing’s disease

JF. Bonneville


Pituitary vs ectopic ACTH secretion – diagnostic challenges



Session 4: Treatment modalities in Cushing’s disease

●       Surgery and perioperative management of patients with Cushing’s disease – J. Honegger

●       Medical management of Cushing’s disease – when and how? – F. Castinetti

●       Role of radiosurgery in treatment of Cushing’s disease – M. Losa




11:00-11:10Coffee break  
11:10-11:50DEBATE 2:  Bilateral adrenalectomy versus medical therapy for treatment of Cushing’s disease after unsuccessful pituitary surgery(ies) – A.Grossman/ M. Gurnell  
11:50-12:50ENEA Young Investigator Oral Presentations  
12:50-13:00Coffee break   

Session 5: Treatment challenges

●       Aggressive corticotroph tumors – G. Raverot

●       Diagnosis and management of Cushing’s syndrome in pregnancy – N. Karavitaki



13:50-15:00Lunch break   

Session 6: Long term consequences of CS

●       Long term morbidity and mortality in patients with Cushing’s syndrome – M. Reincke

●       Long term follow-up and predictors of recurrence of Cushing’s disease – J. Bertherat

●       Recovery of HPA axis after surgery for Cushing’s syndrome – T. Dusek 




16:15-17:45Industry symposium